Презентация crohns disease доклад на Общие темы

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Independent work Gastroenterology – Crohn’s Disease Daserbay Zhibek
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Crohn’s Disease
Crohn’s Disease
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How to use this module
How to use this module
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Epidemiology & Pathology
of Crohn’s Disease
Epidemiology & Pathology of Crohn’s Disease
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Epidemiology
Epidemiology
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Epidemiology
Epidemiology
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Pathology
 It is characterised by patchy transmural inflammation. 
 The chronic inflammatory process leads of thickening of 
the bowel wall and can cause a narrowed lumen.
 In early CD there are prominent lymphoid follicles followed 
by aphthoid ulceration.  Later this progresses to larger deep 
fissuring ulcers separated by normal looking mucosa 
(cobble-stoning), fibrosis, stricturing and fistulation.  These 
changes are often segmentally distributed (skip lesions).
Pathology It is characterised by patchy transmural inflammation. The chronic inflammatory process leads of thickening of the bowel wall and can cause a narrowed lumen. In early CD there are prominent lymphoid follicles followed by aphthoid ulceration. Later this progresses to larger deep fissuring ulcers separated by normal looking mucosa (cobble-stoning), fibrosis, stricturing and fistulation. These changes are often segmentally distributed (skip lesions).
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Pathology
Some of the complications of CD are outlined below:
Fistula formation – abnormal channels of communication
can form in CD between loops of bowel, bladder and skin.
If the CD is in the colon, fistulae can form between the
colon and vagina or between the colon and perineum.  The
diagram on the right shows the beginning of a fistula
formation with a fissure extending though mucosa towards
the muscular wall. Below is a cartoon representation of a
fistula starting from an area of ulceration
Pathology Some of the complications of CD are outlined below: Fistula formation – abnormal channels of communication can form in CD between loops of bowel, bladder and skin. If the CD is in the colon, fistulae can form between the colon and vagina or between the colon and perineum. The diagram on the right shows the beginning of a fistula formation with a fissure extending though mucosa towards the muscular wall. Below is a cartoon representation of a fistula starting from an area of ulceration
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Aetiology & Pathogenesis
The aetiology of Crohn’s disease is unknown.  There are many proposed 
pathogenic mechanisms, some of which are represented in this diagram.
As there is no one cause, it is likely that Crohn’s disease is an outcome of 
interactions between genetic predisposition, environmental factors and the
subsequent reaction of the host immune system.
Aetiology & Pathogenesis The aetiology of Crohn’s disease is unknown. There are many proposed pathogenic mechanisms, some of which are represented in this diagram. As there is no one cause, it is likely that Crohn’s disease is an outcome of interactions between genetic predisposition, environmental factors and the subsequent reaction of the host immune system.
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Genetic Factors
Genetic Factors
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Environmental Factors
Environmental Factors
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The immune system and CD
The immune system and CD
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Clinical features of Crohn’s Disease
Clinical features of Crohn’s Disease
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Clinical Features
Clinical Features
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Clinical Features
Clinical Features
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Intestinal Complications
Intestinal Complications
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Extra-intestinal complications
Extra-intestinal complications
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Extra-intestinal complications
Extra-intestinal complications
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Diagnosis and Management of Crohn’s Disease
Diagnosis and Management of Crohn’s Disease
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Diagnosis
Diagnosis
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Diagnosis
Diagnosis
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Differential Diagnosis
Differential Diagnosis
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Management
Management
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Medical management
Medical management
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Drug Information
Drug Information
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Surgical management
Surgical management
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Prognosis
Prognosis
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Summary
Summary
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The different sections
The different sections
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Case Study
Case Study
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Thank you
I hope this has been of some help to your studies!
Thank you I hope this has been of some help to your studies!
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Reading list
Reading list
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